Registration Dossier
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EC number: 202-764-2 | CAS number: 99-54-7
Henry's Law constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- Henry's law constant
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
- Principles of method if other than guideline:
- dynamic method, similar concurrent flow (wetted wall column) Values are determined based on the use of a wetted wall (desorption) column. The wetted wall column equilibrates an organic solute between a thin film of water and a concurrent flow of gas. Compound-loaden water is introduced into the wetted wall column where it comes in contact with a compound-free gas stream flowing concurrently. The knowledge of flow rates and compound masses present in the separated phase streams enables the direct calculation of HLC.
- GLP compliance:
- no
- H:
- 0 dimensionless
- Temp.:
- 25 °C
- Conclusions:
- The measured HLC of 1,2 -dichloro-4 -nitrobenzene accounts for 3.3 E-4 (dimensionless) or 0.818 Pa*m³/mol (Altschuh et al., 1999).
- Executive summary:
The measured HLC of 1,2 -dichloro-4 -nitrobenzene accounts for 3.3 E-4 (dimensionless) or 0.818 Pa*m³/mol (Altschuh et al., 1999).
Reference
Measured dimensionless Henry's Law Constant (H):
H = 0.00033 (dimensionless)
H = 0.00033 x 8,314 Pa m3/mol K x 298 K = 0.818 Pa m3 mol-1 at 25°C
Bond method: calculated log H = - 3.32
H = 0.00048 (dimensionless) = 1.19 Pa m3 mol-1 at 25°C
Group method: calculated log H = - 2.88
H = 0.0013 (dimensionless) = 3.27 Pa m3 mol-1 at 25°C
The authors argue that the results of the Group method are less reliable than these of the Bond method
Description of key information
The HLC was measured by the means of a dynamic method (wetted wall (desorption) column) at a temperature of 25 °C. The wetted wall column
equilibrates an organic solute between a thin film of water and a concurrent flow of nitrogen gas. Compound-loaden water is introduced into the wetted wall column where it comes in contact with a compound-free gas stream flowing concurrently. The knowledge of flow rates and compound masses present in the separated phase streams enables the direct calculation of HLC. The determined HLC accounts for 0.818 Pa*m³/mol (25 °C) (Altschuh et al., 1999).
Key value for chemical safety assessment
- Henry's law constant (H) (in Pa m³/mol):
- 0.818
- at the temperature of:
- 25 °C
Additional information
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