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EC number: 202-764-2
CAS number: 99-54-7
RS-Freetext:The authors reported the results of a 2.5 year study on thehealth of workers exposed at a 1,2-dichloro-4-nitrobenzeneprocessing plant in the former USSR. The workers wereexposed essentially to 1,2-dichloro-4-nitrobenzene,3,4-dichloroaniline and 3,4-dichloropropionic acid anilide.The skin was affected (chloracne) and also alterations ofperipheral blood including instable methaemoglobinaemiaappearance of Heinz bodies, a tendency towardsreticulolymphocytosis and thrombocytosis, bilirubinaemia anddysproteinaemia. The exposure risk was suspected via dermalabsorption due to the low vapour pressure and the workingconditions. Measurements for uncovered skin gave exposuresto 0.002 - 0.2 mg/dm2 1,2-dichloro-4-nitrobenzene and3,4-dichloroaniline and for covered skin (clothes) 0.0013 -0.02 mg/dm2.For 1,2-dichloro-4-nitrobenzene and 3,4-dichloroaniline themean individual dermal exposure per shift was given with2.535 mg, while after cleaning of the skin the meanindividual burden was still 1.066 mg.Due to the mixed exposure an association of the findingswith exposure to 1,2-dichloro-4-nitrobenzene is uncertain.
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