Registration Dossier

Administrative data

Endpoint:
health surveillance data
Type of information:
other: secondary literature
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature Documentation insufficient for assessment

Data source

Reference
Reference Type:
secondary source
Title:
Hygienic characteristics of propanide manufacture.
Author:
Russkikh VA and Lubyanskii ML
Year:
1984
Bibliographic source:
Gig Tr Prof Zabol 3: 13-16 (Study in Russian; cited from: BUA Report 52 (1,2-Dichloronitrobenzenes), dated Juli 1990)

Materials and methods

Study type:
health record from industry
Principles of method if other than guideline:
migrated dataset

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
migrated dataset

Method

Details on study design:
migrated dataset

Results and discussion

Results:
migrated dataset

Any other information on results incl. tables

RS-Freetext:
The authors reported the results of a 2.5 year study on the
health of workers exposed at a 1,2-dichloro-4-nitrobenzene
processing plant in the former USSR. The workers were
exposed essentially to 1,2-dichloro-4-nitrobenzene,
3,4-dichloroaniline and 3,4-dichloropropionic acid anilide.
The skin was affected (chloracne) and also alterations of
peripheral blood including instable methaemoglobinaemia
appearance of Heinz bodies, a tendency towards
reticulolymphocytosis and thrombocytosis, bilirubinaemia and
dysproteinaemia. The exposure risk was suspected via dermal
absorption due to the low vapour pressure and the working
conditions. Measurements for uncovered skin gave exposures
to 0.002 - 0.2 mg/dm2 1,2-dichloro-4-nitrobenzene and
3,4-dichloroaniline and for covered skin (clothes) 0.0013 -
0.02 mg/dm2.
For 1,2-dichloro-4-nitrobenzene and 3,4-dichloroaniline the
mean individual dermal exposure per shift was given with
2.535 mg, while after cleaning of the skin the mean
individual burden was still 1.066 mg.
Due to the mixed exposure an association of the findings
with exposure to 1,2-dichloro-4-nitrobenzene is uncertain.

Applicant's summary and conclusion

Executive summary:

migrated dataset