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EC number: 202-764-2
CAS number: 99-54-7
RS-Freetext:RATS and MICE : No effects on behaviour and body weights.RATS and MICE: Blood counts and biochemical tests revealed significant changes,
mainly among animals treated with a concentration of 10 mg/m³e.g. RATS: 0.4 mg/m3: no adverse effects were reported;3.6 mg/m3: increase in Heinz bodies (up to 7 %) andreticulocytes (up to 19.6 %);
significantly increased activity of liver catalase
(35.6 versus 26.5[catalase numbers] of control);10 mg/m3: significant changes in blood counts and biochemical tests:
decrease in RBC of 10% towards the 18th day of treatment,
decreased haemoglobin levels from 15.1g% to 12.2 g%,
neutrophilic leucocytosis, pronounced reticulocytosis,
increase in Heinz bodies and in methaemoglobin levels (up to 7.6 %); significantly (sig.) increased activities of serum transaminases
(Glutamic-alanine-transa.: 35.4 versus 28.9 [extinction units] of controls;
Glutamatic-aspartic-transa.: 141.5 versus 121.8 [extinction units] of controls),
sig. liver catalase (47.6 versus 26.5 [cataslase numbers] of controls),
sig. liver diaminooxidase (56.8 versus 41.4 [ug/g tissue] of controls),
sig. increased levels of bilirubin in blood (6.03 versus 2.0 [mg%] of controls),
sig. increased cholesterol level in adrenals (4.7 versus 3.7 [mg/100 g tissue] of controls); histological examination:10 mg/m³: morphological changes of the brain
(cells with hyperchromic nuclei most commonly in the subcortical ganglia).
Inhalation exposure of rats for 4 months against 0.4 to 10 mg/m³ 1,2
-dichloro-4-nitrobenzene yielded a NOAEC of 0.4 mg/m³ based on
significant changes in the hematological parameters from 3.6 mg/m³
onwards including methemoglobinemia and Heinz bodies
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