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EC number: 203-825-6
CAS number: 111-01-3
The study was designed to investigate the systemic
toxicity and potential adverse effects of the test item on reproduction
(including offspring development) and is compatible with the
requirements of the OECD Guidelines for Testing of Chemicals No. 422
“Combined Repeated Dose Toxicity Study with the
Reproduction/Developmental Toxicity Screening Test” (adopted 22 March
The test item Phytosqualan was administered orally
(by gavage) to three groups, each consisting of ten male and ten female
RccHan®:WIST rats, daily for at least 4 weeks (including
two weeks prior to mating, through mating, pregnancy and early lactation
for females) at the following dose levels: 0, 100, 300 and 1000
The dose of 1000 mg/kg can be considered the NOEL. No
differences from the control group were recorded in mean body weight. No
morphological findings were recorded. Regarding motor development, no
differences from the control group were recorded. No macroscopic
findings were recorded at necropsy.
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