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EC number: 203-825-6
CAS number: 111-01-3
The study was designed to investigate the systemic toxicity and
potential adverse effects of the test item on reproduction (including
offspring development) and is compatible with the requirements of the
OECD Guidelines for Testing of Chemicals No. 422 “Combined Repeated Dose
Toxicity Study with the Reproduction/Developmental Toxicity Screening
Test” (adopted 22 March 1996).
The test item Phytosqualan was administered orally (by gavage) to three
groups, each consisting of ten male and ten female RccHan®:WIST rats,
daily for at least 4 weeks (including two weeks prior to mating, through
mating, pregnancy and early lactation for females) at the following dose
levels: 0, 100,300 and 1000 mg/kg/day.
No mortality was recorded in any sex. No test-item-related differences
from the control group were recorded in males. No test item-related
alterations were recorded.
The systemic toxicity NOAEL was 1000 mg/kg/day for male and female (F0
and F1 generation)
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