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EC number: 203-825-6
CAS number: 111-01-3
Table 1 : Individual score of ocular reactions
Mean total scores :
- 1hr : 6.67
- 24hrs : 5.33
- 48hrs : 0.67
- 72hrs : 0
Classification according to EEC criteria
The aim of the study is to determine the irritant and/or corrosive
effects if any, of a test article when instilled ibnto the rabbit eye.
This study was designed to comply with the standards set forth in EPA
Health Effects testing Guidelines, OPPTS Series 870.2400, final
guideline, august 2008.
Three healthy New Zealand White rabbits, free from evidence of ocular
irritation and corneal abnormalities, were dosed with squalane. The test
article (0.1 ml) was placed into the conjunctival sac of one eye of each
rabbit. The contralateral eye served as a control. The eyes were
examined and scored by the Draize technique at 1, 24, 48 and 72hrs.
Sodium fluoresecein dye procedures were used at 24hrs observation
interval. The control eyes were observed at the same time periods.
Observations for mortality, toxicity and pharmacological effects were
recorded at each ocular observation period. Body weights were recorded
pretest. The mean total scores were calculated by adding the total score
for each time period and dividing by the number of animals.
There was no corneal opacity or iritis noted in any observation period.
Conjunctival irritation, noted in 3/3 eyes, cleared within 72hrs.
The control eyes appeared normal at all periods.
There were no abnormal physical signs noted during the observation
According to OPPTS, ocular administration of squalane is not an ocular
According to EEC, squalane does not require risk phrases.
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