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EC number: 203-825-6
CAS number: 111-01-3
No mortality, neither no clinical sign were observed after oral
administration of 1000 mg/kg/day during 14 consecutive days.
The dose-range-finding toxicity study has been realized
according OCDE 407 method on 24 animals (wistar rats - 12 females and 12
males). The test item was administrated by oral gavage at 100, 500 or
1000 mg/kg/day during 14 consecutive days. Animals were observed twice
daily from J0 (oral administration) to J14.
oral (gavage) administration of Phytosqualan to Wistar Hannover rats at
doses up to 1000 mg/kg/day for 14 days resulted in no mortality or
relevant clinical signs.
effects observed on clinical biochemistry analysis such as slightly
lower protein count, lower calcium values and increased ALP values (in
females) with respect to the Control group are considered non-adverse
The relevance of the effects on thyroid, liver and
kidney weights of males treated at 1000 mg/kg remains unclear in the
absence of a microscopic examination. In any case, they should not be
considered toxicologically relevant because there was no evidence of
liver or kidney impairment in the clinical laboratory investigations.
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