Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 248-363-6 | CAS number: 27247-96-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Non-GLP, very low detail level, extremely low sensitivity of the study design (3-fold too short exposure, 4-fold too low concentration, 7-fold too short observation period and doubt whether macroscopic examination was performed) excluding conclusion on classification.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Department of Transportation Regulation 49 CFR 173.343, 1976.
- GLP compliance:
- no
- Remarks:
- prior to GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder: Laboratory Supply Company, Indianapolis, Indiana
- Weight at study initiation: 236-273 g
- Fasting period before study: No
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The rats were exposed to the test compound in a 0.5 cm3 volume stainless steel inhalation chamber. The air flow through the chamber was
148 liters of air/min. The vapor of 2-Ethyl-n-hexyl nitrate was generated by heating the test compound in a glass flask while bubbling nitrogen
into the compound. The concentrations of the test compound in the chamber was calculated by determining the weight of the compound used and
dividing by the total air flow through the chamber during the test. As the stated air flow in the chamber, approximately 15 minutes is required to
reach equilibrium concentration. Therefore, a total exposure time of 75 minutes was used to allow a one-hour exposure to the equilibrium
concentration. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 75 min
- Remarks on duration:
- including equilibration time
- Concentrations:
- 4.6 mg/L (nominal)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- The animals were observed 24 and 48 hours following the exposure to determine the number of death that occurred.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LCLo
- Effect level:
- > 4.6 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 75 min
Applicant's summary and conclusion
- Interpretation of results:
- other: insufficient exposure excluding conclusion
- Remarks:
- Criteria used for interpretation of results: EU
- Executive summary:
No death occured within 48h among ten female rats exposed to 2EHN vapour at 4.6 mg/L (nominal) averaged over 75 min of exposure (incl. equilibration time).
The extremely low sensitivity of the study design when compared to the applicable guideline (3-fold too short exposure, 4-fold too low concentration, 7-fold too short observation period and doubt whether macroscopic examination was performed) excludes any conclusion on classification.
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