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EC number: 248-363-6
CAS number: 27247-96-7
Table 1: Neurochemical effects of intraperitoneal Ethylhexyl nitrate
RNA [γ/mg protein]]
Glutathione [ng/mg protein]
Acetylcholine esterase [nmol/(min mg protein)]
Succinate dehydrogenase [nmol/(min mg protein)]
Each figure is the mean of 5 test animals ± SD
SD = Standard Deviation
The nitroester dose caused a decrease in Glutathione concentration and
an initial decrease in acetylcholine concentration. However, there was
no significant effects on RNA and mitochondrial Succinate dehydrogenate
levels. This decrease is compatible with the Glutathione dependent
deesterification of Glyceryl trinitrate found in vitro (Heppel & Hilmoe
1950) and in vivo (Zitting & Slavolainen 1982).
There was no major structural damage caused by the high exposure to
ethylhexyl nitrate becasue the effects were only temporary and the
enzyme activity is dependent on the lipid structure of the excitable
membrance, which was not damaged. The authours could not explain the
decrease in Acetylcholine esterate, but it is known from the literature
that tetra N-alkylammonium ions interfere with the esterase activity.
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