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EC number: 248-363-6
CAS number: 27247-96-7
1. Nitroglycerin (CAS 55-63-0) and reduced Glutathione (GSH, CAS
70-18-8) were found to undergo a reaction forming Nitrite (CAS
14797-65-0) and Oxidized glutathione (CAS 27025-41-8). Reduction of
Nitroglycerin preceded via hydrolysis because inorganic nitrate did not
react with GSH. The rate of nitrite formation was appreciable in neutral
aqueous solution but increased rapidly as the pH became more alkaline.
GSH could be replaced by cysteine (CAS 52 -90 -4) or cysteinylglycine
2. An enzyme has been purified from hog liver acetone powder which
catalyses the reaction between nitroglycerin and GSH. It had a pH
optimum between 7 and 8 (about physiologic pH) and was sensitive to
traces of cupric salts. The enzyme did not stimulate the reaction
between cysteine and nitroglycerin.
3. When crude tissue extracts were incubated with nitroglycerin, nitrite
was formed. The rate and extent of the reaction could be correlated with
the GSH content of these extracts.
4. When inorganic nitrate was incubated with GSH, no measurable amount
of nitrite was formed. Thus the reaction seems specific to
5. The attached figure (figure 2 of the publication) shows the kinetics
of the in vitro transformation. It can be concluded that the half-life
of nitroglycerin is less than two hours based on the formation of
nitrite in the figure.
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