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EC number: 248-363-6
CAS number: 27247-96-7
The test item was first administered to a single male New Zealand
White rabbit. Since the test item was not severely irritant on this
first animal, it was then evaluated simultaneously in two other animals.
A single dose of 0.1 mL of the undiluted test item was instilled
into the left conjunctival sac. The right eye was not treated and served
The eyes were not rinsed after administration of the test item.
Ocular reactions were observed approximately 1 hour, 24, 48 and
72 hours after the administration.
The mean values of the scores for chemosis, redness of the
conjunctiva, iris lesions and corneal opacity were calculated for each
The interpretation of results was carried out according to the
classification criteria laid down in Council Directive 67/548/EEC (and
A slight chemosis was noted in all animals on day 1. Slight or
moderate redness of the conjunctiva was observed in all animals on day
1; persisting until day 2 in two of them. A clear discharge was recorded
on day 2 in 1/3 animals.
Mean scores calculated for each animal over 24, 48 and 72 hours
were 0.0, 0.0 and 0.0 for chemosis, 0.0, 0.3 and 0.3 for redness of the
conjunctiva, 0.0, 0.0 and 0.0 for iris lesions and 0.0, 0.0 and 0.0 for
Under the experimental conditions of the study, the test item
2-Ethylhexyl nitrate was slightly irritant when administered by ocular
route to rabbits.
However, according to the classification criteria laid down in
Council Directive 67/548/EEC (and subsequent adaptations), the test item
should not be classified as irritating to the eyes.
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