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EC number: 248-363-6
CAS number: 27247-96-7
Results of Nicolau et al. 2008
Carbon balance calculation, as well as organic-carbon measurement,
indicated a release of metabolites in the culture medium. Further
analysis by gas chromatography revealed that a single metabolite
accumulated during growth. This metabolite had a molecular mass of 114
Da as determined by gas chromatography/mass spectrometry and was
provisionally identified as 4-ethyldihydrofuran-2(3H)-one by liquid
chromatography-tandem mass spectrometry analysis. Identification was
confirmed by analysis of the chemically synthesized lactone. Based on
these results, a plausible catabolic pathway is proposed whereby 2-EHN
is converted to 4-ethyldihydrofuran-2(3H)-one, which cannot be
metabolized further by strain IFP 2173. This putative pathway provides
an explanation for the low energetic efficiency of 2-EHN degradation and
its poor biodegradability.
Results of Nicolau et al. 2009
In a further publication using two-dimensional gel electrophoresis and a
shotgun proteomic approach the proposed pathway involving an initial
attack by an alkane hydroxylase and one turn of beta-oxidation, leading
to the accumulation of a gamma-lactone as a dead-end product is
discussed using the data on the induced enzymatic changes found.
Results of Solano-Serena et al. 2009
In aerobic liquid cultures, biodegradation of 2-EHN was assessed in
biphasic liquid cultures using an inert non-aqueous phase liquid such as
2,2,4,4,6,8,8-heptamethylnonane (HMN) as solvent for the hydrophobic
substrate. 2-EHN was found to be biodegradable by microbial communities
from refinery wastewater treatment plants, but was recalcitrant to those
of urban wastewater treatment facilities. In liquid cultures with HMN
phase as non-aqueous phase liquid, some Mycobacterium austroafricanum
strains were found to degrade and mineralize 2-EHN significantly.
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