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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
The exposure period is longer than required by the guideline. This can be regarded as a worst-case scenario.

Data source

Reference
Reference Type:
review article or handbook
Title:
Monoisopropanolamine: acute toxicological properties and industrial handling hazards / HET K-5066-(4)
Author:
The Dow Chemical Company
Year:
1981
Bibliographic source:
Cited in: American Chemistry Council Amines Panel ICCA Iuclid Data Set, Nov. 22, 2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: aerosol
Duration of exposure:
6 h
Concentrations:
Nominal concentration 1126 ppm (3460 mg/m3)
No. of animals per sex per dose:
6
Details on study design:
- 14-day observation period
- Examinations: mortality, clinical signs, body weight (frequency not indicated); macroscopy

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 3 460 mg/m³ air
Exp. duration:
6 h
Mortality:
no mortality occurred
Clinical signs:
other: no adverse effects
Body weight:
no treatment related effects
Gross pathology:
slightly enlarged livers (2/6)

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LC50 is > 1126 ppm (3460 mg/m3) under these test conditions.