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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1973
Reference Type:
publication
Title:
Occupational health case report - No. 8. Monoisopropanolamine
Author:
Hervin RL, Lucas JB
Year:
1974
Bibliographic source:
Journal Of Occupational Medicine No. 16, No. 5

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
After a written request of a representative of employees to NIOSH to evaluate potential hazards associated with the use of monoisopropanolamine (MIPA) and titaniurn dioxide (TiO2) in the milling department of a large plant producing TiO2. Approximately 70 operators, cleanup, and maintenance employees were occasionally exposed to MIPA and TiO2 (semisaturated with MIPA) during maintenance operations or when a leak occurs in the system. 15 randomly selected individuals were questioned regarding their general health.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
occupational
Subjects:
Approximately 70 operators, cleanup, and maintenance employees were occasionally exposed to MIPA and TiO2 (semisaturated with MIPA) during maintenance operations or when a leak occurs in the system.
15 randomly selected individuals were questioned regarding their general health.
Route of exposure:
dermal
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified
Details on exposure:
- occasionally, exposed to MIPA
Examinations:
- attempts were then made to elicit present symptoms or a past history of respiratory or cutaneous disorders
- individually interviewed

Results and discussion

Clinical signs:
Monoisopropanolamine represented a definite cutaneous hazard upon direct contact with the skin to workers.
Nine individuals reported by the Union as having past or present health complaints were individually interviews and examined during the two survey periods. One Individual was re-axmined during the second visit.

Applicant's summary and conclusion

Executive summary:

In a questioning after a written request of a representative of employees to NIOSH, monoisopropanolamine (MIPA) and titaniurn dioxide (TiO2) in the milling department of a large plant producing TiO2 were investigated for its hazard potential.

MIPA represented a definite cutaneous hazard upon direct contact with the skin to those workmen failing to utilize proper protective equipment (direct contact). Five individuals of 15 questioned employees experienced an irritant contact dermatitis after direct skin exposure to MIPA. Most employees working with the substance recognized irritant effects when not wearing appropriate protective clothing at the time of contact.

Irritation of the upper respiratory tract and eye irritation were noted by another rindividual.