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EC number: 485-320-2 | CAS number: 221667-31-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Sep - 23 Nov 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Study type:
- direct photolysis
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-2 (Photodegradation Studies in Water)
- Qualifier:
- according to guideline
- Guideline:
- other: Journal of the European Communities, Commission Directive, 95/36/EC
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- yes
- Analytical method:
- high-performance liquid chromatography
- Details on sampling:
- - Sampling intervals for the parent: 0, 4, 8, 12, 20, 24, 30, and 48 hours post treatment
- Sampling methods for the volatile compounds, if any: Volatile traps were collected at each sampling interval (0, 4, 8, 12, 20, 24, 30, and 48 hours post treatment)
- Sampling intervals/times for pH measurements: pH measurements were performed at each sampling interval (0, 4, 8, 12, 20, 24, 30, and 48 hours post treatment)
- Sampling intervals/times for sterility check: Sterility checks and pH measurements were performed at each sampling interval.
- Sample storage conditions before analysis: Samples were stored frozen until analysis, and were analyzed within 3 days after sampling. - Buffers:
- - pH: pH 7
- Type and final molarity of buffer: Potassium phosphate, 0.01 M
- Composition of buffer: KH2P04 was dissolved in Milli-Q water (1 .36 g/ L) and the pH was adjusted to pH 7 by addition of 1 M potassium hydroxide. - Light source:
- Xenon lamp
- Light spectrum: wavelength in nm:
- > 290
- Details on light source:
- - Emission wavelength spectrum: >290 nm
- Filters used and their purpose: Suprax® filter (DSET) filter
- Light intensity at sample and area irradiated: 680 W/cm2
- Relative light intensity based on intensity of sunlight: The photolysis experiment was conducted so that the exposure time and intensity in the
Suntest unit would approximate natural solar radiation found in Phoenix, Arizona
- Other: Nature of light source is Suntest XLS+ unit containing a Heraeus xenon-arc lamp (ATLAS; Chicago, IL) - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test apparatus/vessels: Sterile quartz glass vessels and ground glass volatile traps were used for irradiated test systems. For dark control test systems, sterile amber bottles with crimp caps were used.
- Sterilisation method: 0.2 µm sterile filter
- Details of traps for volatile, if any: Soda lime, Static for Irradiated
TEST MEDIUM
- Volume used/treatment: 20 mL
- Identity and concentration of co-solvent: Acetonitrile(<0.1%)
REPLICATION
- No. of replicates (dark): 1 per interval per label
- No. of replicates (irradiated): 2 per interval per label - Duration:
- 48 h
- Temp.:
- 25 °C
- Initial conc. measured:
- 1.06 other: mg/L (Methoxybenzoyl)
- Duration:
- 48 h
- Temp.:
- 25 °C
- Initial conc. measured:
- 1.03 other: mg/L (Sulfonylbenzamide)
- Reference substance:
- yes
- Remarks:
- three reference substances
- Dark controls:
- yes
- Test performance:
- The irradiation was performed continuously. The maximum period of continuous light exposure was 48 hours. The study was terminated after 48 hours as it had reached two half-lives of the parent.
- DT50:
- 1 d
- Test condition:
- The first order experimental half-life values of the methoxybenzoyl label and sulfonylbenzamide label in the irradiated samples were 24.5 and 23.2 hours respectively.
- DT50:
- 3.5 d
- Test condition:
- calculated for a solar summer days at Phoenix, New River Arizona (USA, latitude 33.26 N)
- DT50:
- 5 d
- Test condition:
- calculated for a solar summer days in Athens (Greece, latitude 38.03 N)
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Validity criteria fulfilled:
- not applicable
Reference
Mass Balance:
Material balance for the methoxybenzoyl label, was 99.2 ± 0.6% (range = 97.6% to100.2%) and 100.2 ± 0.6% (range = 99.0% to 100.9%) of the applied activity in the irradiated and dark (non-irradiated) samples, respectively. Material balance forsulfonylbenzamide label, was 100.7 ± 0.8% (range = 98.9% to 102.5%) and 100.6 ±0.4% (range = 99.9% to 101.4%) of the applied activity in the irradiated and dark (nonirradiated) samples, respectively.
Results:
AE 0001789 degraded very rapidly via aqueous photolysis, with half lives of 24.5 and 23.2 hours for the methoxybenzoyl label and sulfonylbenzamide label, respectively. This was equivalent to a half-life of 3.5 solar days in Phoenix, Arizona (USA). The half-life values were not calculated for the dark control samples due to no degradation. The kinetics results are summarized in the table below:
Half-life, DT50 and DT90:
Label |
First Order Regression |
DT50 (hrs) |
DT90 (hrs) |
||
Half-life (hrs, days) |
Equation c(t) = c0 * e-kt |
R² |
|||
Methoxybenzoyl |
24.5, 1.02 |
c(t) = 100xe-0.0282 t |
0.993 |
24.5 |
81.5 |
Sulfonylbenzamidemide |
23.2, 0.97 |
c(t) = 100xe-0.0298 t |
0.995 |
23.2 |
77.2 |
Formation and Decline of Transformation Products:
Two major photodegradation products were found in this study and increased during the irradiation period. In the methoxybenzoyl label, 2-methoxy benzoic acid was the major photolyte and accounted for a maximum of 30.6% of the applied activity. In the sulfonylbenzamide label AE0001789-sulfonic acid was the major photolyte and accounted for a maximum of 55.7% of applied activity. There were multiple minor products (>10% of applied activity) formed in both the labels.14CO2accounted for a maximum 2.7% (methoxybenzoyl label) and 0.1% (sulfonylbenzamide label) of the applied radioactivity at study termination.
Description of key information
DT50: 1.0 – 5.0 days (under artificial light at pH 7, EPA 161-2)
Key value for chemical safety assessment
- Half-life in water:
- 5 d
Additional information
In the available GLP study (M-281558-01-1), the photolysis of Cyprosulfamide was studied in a sterile aqueous buffer solution at pH 7 under exposure to simulated sunlight in the laboratory with a nominal test concentration of 1 mg/L for 48 hours at 25 °C (EPA 161-2). Based on the experimental half-life of 1.0 day (24 h), the half-life of the test substance under environmental conditions is calculated to be 3.5 solar summer days at Phoenix, New River Arizona (USA, latitude 33.26 N), or 5.0 solar summer days in Athens (Greece, latitude 38.03 N).
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