Registration Dossier
Registration Dossier
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EC number: 485-320-2 | CAS number: 221667-31-8
Endpoint summary
Administrative data
Description of key information
Additional information
The ecotoxicological profile of the substance has been well defined. Short term and long term tests with species of three different trophic levels are available for the substance (fish, invertebrates, algae and aquatic plants).
Acute toxicity tests (96 h) on freshwater and marine fish species (bluegill sunfish, rainbow trout and sheepshead minnow) resulted in no effects up to the highest tested concentration. The LC50 (96 h) for short-term tests with freshwater fish is therefore ≥101 mg a.i./L (arith. mean measured). For the saltwater species sheepshead minnow a LC50 (96 h) of ≥106 mg a.i./L (arith. mean measured) was determined. A chronic test on fathead minnow (early life stage study over 35 days) resulted in a NOEC of 4.67 mg/L (arith. mean measured) based on growth (length and weight).
Acute toxicity tests on freshwater invertebrates (Daphnia magna), resulted in an EC50 of > 100 mg a.i./L (nominal) and no toxic effects were observed during the study. The EC50 for marine invertebrates were >100 mg a.i./L (arith. mean measured) for Americamysis bahia and >94 mg a.i./L (arith. mean measured) for Crassostrea virginica.
The 21-day exposure of daphnia to the test substance resulted in a NOEC of 57.2 mg a.i./L and a LOEC of 111.6 mg a.i./L based on reproduction and growth.
For freshwater algae (Pseudokirchneriella subcapitata), no toxic effects occurred up to the highest tested concentration of 100 mg a.i./L (nominal). The 72h EC50 (growth rate) was therefore >99.7 mg/L (arith. mean measured) and the NOEC (growth rate) ≥99.7 mg/L (arith. mean measured).
Additionally a higher tiered test was performed in order to determine the potential toxicity of the substance to Lemna gibba. The determined NOEC (7 d) was 51.1 mg a.i./L for frond number, biomass and growth rate for frond counts, respectively. The EC50 (7 d) for all endpoints measured was >104 mg a.i./L which was the highest concentration tested. Fronds in all levels appeared normal as compared to the control.
The effects of the substance on the respiration of microorganisms (activated sludge) was examined in a study according to OECD 209. No effects >25% on nitrogen or carbon transformation, compared to the controls, was observed.Therefore, inhibition of the degradation activity of activated sludge is not anticipated.
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