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EC number: 946-188-6
CAS number: -
In a combined repeated dose toxicity study with
reproduction/developmental toxicity screening test in rats via the oral
route, conducted according to current OECD guideline 422 and in
compliance with GLP, no changes attributable to treatment were noted in
offspring. There was no effect of maternal treatment on the number of
implantations, post-implantation loss and live birth index, sex ratio,
and subsequent offspring survival to day 13 of age at dosages of 100,
300 or 1000 mg/kg bw/day. There was also no effect of treatment with the
test substance on offspring growth and development, indicated by
clinical signs, offspring body weight or body weight gain, visible
nipple count in male offspring on day 13 post partum, or ano-genital
distance at 100, 300 or 1000 mg/kg bw/day. The NOEL was 1000 mg/kg
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