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EC number: 946-188-6
CAS number: -
In a combined repeated dose toxicity study with
reproduction/developmental toxicity screening test in rats via the oral
route, conducted according to current OECD guideline 422 and in
compliance with GLP, no changes attributable to treatment were noted for
the examined reproductive toxicity parameters at 100, 300 or 1000 mg/kg
bw/day. There was no effect of treatment on estrous cycle during the
pre-pairing phase of the study or at termination. Mating performance as
assessed by the number of paired animals that mated was unaffected.
There was no effect on fertility, as assessed by the number of females
that achieved pregnancy. The intergroup distribution of gestation length
observed during the study did not indicate any obvious effect of
treatment. The NOEL was 1000 mg/kg bw/day.
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