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EC number: 946-188-6
CAS number: -
Results after treatment for 6 hours with Reaction mass of
Cucurbituril, Cucurbituril and Cucurbituriland the controls:
Ab-sorbanceWell 1(Tissue 1/2)
Ab-sorbanceWell 2 (Tissue 1/2)
Mean Absor-bance (Tissue 1/2)
Mean Absorbance* Tissue 1 and 2 minus
Mean Absorbance of2 Tissues*
Rel. Absorbance [%]Tissue 1 and 2**
Absolute Value of the Difference of the Rel. Absorbances [%]Tissue 1 and 2
Mean Rel. Absorbance
vitro GLP study was performed to assess the eye irritation potential
of the test item "Reaction mass of Cucurbituril, Cucurbituril and
Cucurbituril" by means of the Human Cornea Model Test in accordance
with OECD test guideline 492. Additional
tests with viable or freeze-killed tissues were not performed, since the
test item was not coloured intensively, did not dye water or
isopropanol, and did not reduce MTT.
50 mg of the test item or 50 µL of the controls, respectively, were
applied to each of duplicate EpiOcular (TM) tissue for 6 hours. Treatment
with the positive control induced a decrease in the mean relative
absorbance compared with the negative
control to 31.8%, thus the validity of the test system is ensured. The
acceptance criteria were met. The viability of tissue treated with the
test item was 89.6
the viability of tissues treated with the test item did not decrease
below 60%, the test item is not considered to possess an eye irritating
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