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EC number: 946-188-6
CAS number: -
Acute Oral Toxicity: LD50 >5000 mg/kg bw female Wistar rats (read-across from analogue substance).
LC50 (rat, inhalation, 4h) > 5.35 mg/L
The objective of the study was to assess the toxicity of test item
CUCURBITURIL when administered as a single oral gavage dose to rats.
The results of the study allow the test item to be ranked according to
most classification systems currently used. Study performed in
accordance with the study plan, OECD 423 (17th December 2001),
Commission Regulation (EC) NO 440/2008 of 30 May 2008, B.1.Tris, EPA
Health Effects Test Guidelines (OCSPP 8770.1100), United States, EPA
712-C-98-190 (1998) and the Principles of Good Laboratory Practice
(Hungarian GLP Regulations: 42/2014. (VIII. 19.) EMMI decree of the
Ministry of Human Capacities which corresponds to the OECD GLD,
Under the conditions of this study, the acute oral LD50
value of the test item CUCURBITURIL was found to be above 5000
mg/kg bw in female CRL: (WI) rats. According to the GHS criteria,
CUCURBITURIL can be ranked as “Unclassified” for acute oral exposure.
Salivation was seen in 2/5 males on return to home cage, resolving by the end of the working day check.
There were no test item-related deaths, macropathology findings or effects on body weight in an acute nose-only inhalation study in rats in accordance with OECD guideline 433. Under the conditions of this study the LC50 (4-hour) is in excess of 5.35 mg/L for male rats.
The single-dose oral toxicity of Cucurbituril hydrochloride hydrate
was performed according to the acute toxic class method in CRL: (WI)
rats. Initially, one female was treated at a dose level of 5000 mg/kg bw
by gavage after an overnight food withdrawal. Food was made available
again 3 hours after the treatment. The test item was administered
formulated in Methyl cellulose 1% at a concentration of 500 mg/mL at a
dosing volume of 10 mL/kg bw. The test item did not cause mortality and
two further animals were treated at the same dose level. Clinical
observations were performed at 30 minutes, 1, 2, 3, 4 and 6 hours after
dosing and daily for 14 days thereafter. Body weight was measured on
Days -1, 0 and 7 and Day 14 before necropsy. All animals were subjected
to a necropsy and a macroscopic examination.
The test substance did not cause mortality in these animals, and did not
cause any test substance related effects on the animals. There were no
changes in body weight gains or any macroscopic findings. Therefore, no
further testing was required according to OECD 423 and Commission
Regulation (EC) NO 440/2008 of 30 May 2008, B.1.Tris. Under the
conditions of this study, the acute oral LD50 value of Cucurbituril
hydrochloride hydrate was found to be above 5000 mg/kg bw in female CRL:
Based on the available data, the test substance does not require classification for acute oral and inhalation toxicity according to the CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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