Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01 Augut 2017 to 15 October 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
2004
Deviations:
no
Qualifier:
according to
Guideline:
other: EU method A.24 (partition coefficient, HPLC method)
Version / remarks:
2016
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
-1.68
Temp.:
24 °C
pH:
7
Remarks on result:
other: pH not reported

.

Conclusions:
The log Pow at 24 °C was -1.68.
Executive summary:

The purpose of this GLP study was to determine the partition coefficient with the HPLC method in accordance with current OECD and EU testing guidelines. The capacity factors k and log Pow were calculated based on the calibration data obtained with the reference substances. The retention time of the test item was outside the range of retention times obtained for the six reference items which corresponded to log Pow values in the range betwen 0.3 and 4.0. The log Pow value for the test item derived by extrapolation was -1.68

Description of key information

The key value is taken from a GLP study in accordance with OCED Guideline no. 117 and EU Method A.24, using the HPLC method.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.68
at the temperature of:
24 °C

Additional information

For the calculation only the biggest peak (of 3) was considered. The retention time was outside the retention times of the 6 reference standards, ranging in log Pow value from 0.3 to 4.0.