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EC number: 201-808-8
CAS number: 88-19-7
Table 2. Mortality of rats after single oral administration of
No. of animals
LD50 value (mg/kg)
An Acute Oral Toxicity test was performed according to OECD 401, under
GLP conditions. A total of 40 Sprague-Dawley (Crj: CD) male and female
(20M/20F) rats were divided in 4 groups consisting of 5 animals per
group and received a single oral administration of 700, 1000, 1400 and
2000 mg/kg of the test item. All animals were subject to daily
observations and weekly determinations of body weight. Necropsy was
performed on the day of their death or after sacrifice, at the end of
the observation period. No deaths were observed in males at any dose
tested, but 3 females in the 1400 mg/kg group and 2 females in the 2000
mg/kg group died. Both males and females showed severe toxic symptoms
such as sedation, weakness, laterality, non-responsiveness to stimuli,
respiratory distress, decreased respiratory rate, decreased body
temperature, catalepsy, etc. immediately after administration. Some
suppression of body weight gain was observed in most groups the second
day after administration, but it normalized thereafter. In the necropsy
findings of the death cases, it was presumed that the main cause of
death was a strong central depressant action, because there were no
organic changes caused by the test substance leading to the death. From
these facts, it was estimated that the LD50 value of
o-toluenesulfonamide under this test condition was between 1000 and 2000
mg/kg for females and more than 2000 mg/kg for males.
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