Toluene-2-sulphonamide

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1998

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Version / remarks:

1992

Deviations:

no

GLP compliance:

yes

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Oryzias latipes

Details on test organisms:

TEST ORGANISM
- Common name: medaka (rice fish)
- Strain: Oryzias latipes

Test type:

semi-static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Test temperature:

24 ± 1 ºC

Nominal and measured concentrations:

100 mg/L (nominal)

Details on test conditions:

TEST SYSTEM
- Material, size, headspace, fill volume: volume 5.0 L
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): every 48 hours
- No. of organisms per vessel: 10 per concentration

OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light - 8 hours dark (room light)

EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality

Reference substance (positive control):

not specified

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

not specified

Conclusions:

The 96h-LC50 of the test item in fish is ≥ 100 mg/L.

Executive summary:

An acute fish toxicity test was conducted according to OECD 203, under GLP conditions. A limit test was performed under semi-static conditions (renewal rate 48h). 10 fish per concentration were exposed to 100 mg/L test item or the control for 96 h at 24 ± 1 ºC. The 96h-LC50 of the test item in rice fish (Oryzias latipes) was determined to be ≥ 100 mg/L, based on nominal concentration.

Description of key information

Key study. Test method according to OECD 203, GLP study. The 96h-LC50 of the test item in rice fish (Oryzias latipes) was determined to be ≥ 100 mg/L, based on nominal concentration.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

100 mg/L