Registration Dossier
Registration Dossier
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EC number: 201-808-8 | CAS number: 88-19-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: medaka (rice fish)
- Strain: Oryzias latipes - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 24 ± 1 ºC
- Nominal and measured concentrations:
- 100 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Material, size, headspace, fill volume: volume 5.0 L
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): every 48 hours
- No. of organisms per vessel: 10 per concentration
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light - 8 hours dark (room light)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 96h-LC50 of the test item in fish is ≥ 100 mg/L.
- Executive summary:
An acute fish toxicity test was conducted according to OECD 203, under GLP conditions. A limit test was performed under semi-static conditions (renewal rate 48h). 10 fish per concentration were exposed to 100 mg/L test item or the control for 96 h at 24 ± 1 ºC. The 96h-LC50 of the test item in rice fish (Oryzias latipes) was determined to be ≥ 100 mg/L, based on nominal concentration.
Reference
Description of key information
Key study. Test method according to OECD 203, GLP study. The 96h-LC50 of the test item in rice fish (Oryzias latipes) was determined to be ≥ 100 mg/L, based on nominal concentration.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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