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EC number: 201-808-8 | CAS number: 88-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23/06/1975 - 30/09/1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", Japan
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Details on sampling:
- - Sampling intervals/frequency for test organisms: Analysis of test fish was conducted four times at 2, 3, 4 and 6 weeks after the start of breeding; analysis were performed immediately after collection in 2 replicates.
- Sampling intervals/frequency for test medium samples: Twice per week, analytical samples were collected from each of the test water tanks in the first and second concentration areas, and quantitatively analyzed the test substances by a gas chromatograph (GC) method immediately after collection.
- Sample storage conditions before analysis: not applicable.
- Details on sampling and analysis of test organisms and test media samples (e.g. sample preparation, analytical methods):
- Pretreatment of water samples: extraction for GC analysis.
- Pretreatment of test organism samples: fish samples were crushed, treated with anhydrous sodium sulfate and chloroform and the filtrate was purified twice by column cromatographic method. The eluted fraction containing the test item was analysed by GC. - Vehicle:
- no
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: carp
- Strain: Cyprinus carpio
- Source: not specified
- Length at study initiation (length definition, mean, range and SD): 10 cm on average
- Weight at study initiation (mean and range, SD): 30 g on average - Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
- Total depuration duration:
- 0 wk
- Test temperature:
- 25 ± 2 ºC
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 L glass covered glass tank.
- Type (delete if not applicable): closed.
- Material, size, headspace, fill volume: glass, size 100 L.
- No. of organisms per vessel: 15
- No. of vessels per concentration (replicates): 2
RANGE-FINDING / PRELIMINARY STUDY
- Test concentrations: not specified.
- Results used to determine the conditions for the definitive study: A preliminary study of the 48h-TLm of the test item on Rice fish (Oryzias latipes) was performed according to method JIS K0102. The 48h-TLm of the test item on fish was found to be 335 mg/L. - Nominal and measured concentrations:
- Nominal concentrations: 3 mg/L in 1st concentration area, 0.3 mg/L in 2nd concentration area.
- Reference substance (positive control):
- not required
- Lipid content:
- 4.3 %
- Key result
- Conc. / dose:
- 3 mg/L
- Temp.:
- 25 °C
- Type:
- BCF
- Value:
- >= 0.4 - <= 0.9 L/kg
- Basis:
- not specified
- Time of plateau:
- 6 wk
- Calculation basis:
- steady state
- Key result
- Conc. / dose:
- 0.3 mg/L
- Temp.:
- 25 °C
- Type:
- BCF
- Value:
- >= 0.8 - <= 2.6 L/kg
- Basis:
- not specified
- Time of plateau:
- 6 wk
- Calculation basis:
- steady state
- Details on results:
- - Mortality of test organisms: no.
- Behavioural abnormalities: not reported.
See any other details on results incl. tables. - Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the study results, the test item has a BCF ≤ 2.6 L/kg in carp (worst case scenario).
- Executive summary:
A bioaccumulation study of the test item in fish was performed according to Bioaccumulation test of a chemical substance in fish or shellfish (MITI No.1, 1974), equivalent to OECD 305C. Two levels of concentration as low as possible within the analytical limits (3 mg/L and 0.3 mg/L) were used, based on the results of the 48h-TLm determination of the test item in rice fish (Oryzias latipes), according to JIS K0102. The study was performed for 6 weeks on groups of Cyprinus carpio, along with periodical analytical determinations of the test item concentration in the tank water and in the test specimens by means of a validated analytical method. The BCF was determined at 2, 3, 4 and 6 weeks. The BCF values obtained ranged between 0.4 - 0.9 L/kg (3 mg/L) and 0.8 - 2.6 L/kg (0.3 mg/L). Therefore, the BCF of the test item is ≤ 2.6 L/kg in carp.
Reference
Table 1. Bioaccumulation test results.
2 W | 3 W | 4 W | 6 W | ||
1st Concentration area (3 ppm) |
Test substance concentration (ppm) |
3.2 | 3.4 | 3.4 | 3.4 |
Bioconcentration factor (L/kg) |
0.5 | 0.6 | 0.9 | 0.9 | |
0.6 | 0.4 | 0.6 | 0.8 | ||
2nd Concentration area (0.3 ppm) |
Test substance concentration (ppm) |
0.26 | 0.30 | 0.31 | 0.30 |
Bioconcentration factor (L/kg) |
* | 0.8 | ** | 2.6 | |
* | 0.8 | ** | 1.0 |
* No results were obtained, because all values of concentration in fish were under blank.
** Result was not determined, because analytical value in fish was trace.
Description of key information
Key study. Method according to MITI No.1, equivalent to OECD 305C. The test item has a BCF ≤ 2.6 L/kg.
Key value for chemical safety assessment
- BCF (aquatic species):
- 2.6 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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