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EC number: 201-808-8
CAS number: 88-19-7
Table 1. Elimination of 14C by rat and given [14C]toluene-2-sulphonamide
% of dose of 14C in (CL)
92 ( 83-1 02)
A study on the metabolism and excretion of the test item (14C-labelled)
was performed in female Wistar rats. A single dose of 20, 125 or 200
mg/kg radiolabelled test item was administered via oral gavage to 3
females each and the concentrations of the test item in urine and faeces
were determined daily by TLC and GC-MS. The metabolites were identified
and quantified. A study in humans (2M, 1F) was conducted in parallel to
observe similarities. The 20 mg/kg doses were rapidly eliminated by rats
(92% in 24 h), mostly in urine (88%), with little (5%) in the faeces.
Larger oral doses were eliminated more slowly but the overall
distribution of 14C between urine and faeces was unchanged. The main
metabolite of [Me-14C] toluene-2-sulphonamide in rat and man is
2-sulphamoylbenzyl alcohol with smaller amounts of saccharin,
2-sulphamoylbenzoic acid, N-acetyltoluene-2-sulphonamide, and with
little excreted as unchanged compound.
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