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EC number: 442-390-9
CAS number: 40573-09-9
The dermal irritation potential of the test article was evaluated in New
Zealand White rabbits (3 female). The study was conducted according to
OECD GLP (1999). The test method was based on OECD 404 (1992), EEC
Method B.4. (1992) and US EPA OPPTS 870.2500 (1998). Prior to exposure
(24 hours) the hair on the left flank of each animal (25 mm2) was
clipped. Each animal was treated with 0.5 mL of the test article dosed
on a 2.5 cm2 cellulose patch, placed on a piece of surgical plaster and
covered with a semi-occlusive bandage. The patch was left in place for 4
hours, after which the remaining test article was removed from the
exposure site with warm water. The skin was examined for erythema and
edema at 1, 24, 48, and 72 hours. Animals were observed daily for
clinical signs and mortality. No abnormal clinical signs were observed
in any animals during the study period. No erythema or edema was
observed in any animal at any time period during the study. Based on the
results of the study, the test article is not irritating to skin.
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