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EC number: 442-390-9
CAS number: -
The eye irritation potential of the test material was determined in New
Zealand White rabbits (3, female). The study was conducted according to
OECD GLP (1999). The test method was based on OECD 405 (1987), EEC
Method B.5 (1992), and US EPA OPPTS 870.2400 (1998). 0.1 mL of the test
material was instilled in the conjunctival sac of the left eye of each
animal. The right eye of each animal was left untreated to serve as a
control. 24 hours after administration the treated eyes were washed
thoroughly with isotonic saline. The eyes were examined at 1, 24, 48,
and 72 hours. At 24 and 72 hours, the eyes were further examined for
corneal lesions under UV light after instillation of one drop of a 0.01%
fluorescein-sodium solution. The cornea (0-4), Iris (0-2), and
Conjunctivae (Redness: 0-3, Chemosis: 0-4, and Discharge; 0-3) were
examined and scored appropriately at each of the observation period. A
conjunctivae redness score of 1 was observed in a single animal at the
24 hour observation period and had resolved by the 48 hour observation.
No other scores were noted at any other animals at any other point
during the study. Based on the results of the study, the test material
is not an eye irritant.
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