Registration Dossier
Registration Dossier
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EC number: 251-718-8 | CAS number: 33885-52-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
An experimentalstudy was performed to assess the bioconcentration of Pinyl Isobutyraldehyde in Cyprinus carpiounder flow through conditions. The test material in this test is 50% the aldehyde type (the registered material) and half the acetal version of this aldehyde, with two additional C-atoms. The focus in this summary will be on the aldehyde constituent and its primary degradation product, the alcohol.The study was conducted in accordance withJapanese guidelinesand GLP principles equivalent to OECD TG 305. A solvent was used due to the limited solubility of the substance.During the uptake phase, groups of 28 carp were exposed for 28 days to two concentrations of test substance dispersed with N-N-dimethylformamide and 14 fish exposed to untreated control. Nominal test concentrations of 1 and 10µg/Lwere used and based on an acute toxicity test using Oryzias latipes(rice fish). Concentrations of the test item in water were maintained >= 86% of the nominal concentrations and the variations were within ±20% of the average measured concentrations.The lipid content of the fish (as mg/kg wet weight) at the end of the experiment did not differ from that at the start by more ± 25%.The BCF values for the Aldehyde constituent (the registered substance) was < 27 l/kg. Itsmetabolite being the alcohol derivative:α,α,6,6-tetramethyl-bicyclo[3.1.1 ]hept-2-ene-2-propanol, showed a BCF of 32.Overall Pinyl isobutyraldehyde as the registered substance has no bioaccumulation potential (BCF < 100 l/kg).
(For completeness: the BCF values of Acetal constituent was roughly 300 and 400 at concentrations of 1 and 10 µg/L, respectively, which were reached within 21 days).
Key value for chemical safety assessment
- BCF (aquatic species):
- 27 L/kg ww
Additional information
Value is '< ' , i.e. < 27 L/kg ww.
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