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EC number: 251-718-8
CAS number: 33885-52-8
In accordance to OECD guideline 438 and GLP the test substance was
examined for its in vitro eye irritating potential using the Isolated
Chicken Eye (ICE) Test. In the ICE test, 3 eyes were exposed to 30 µL
test substance for 10 seconds. In addition, one negative control eye (30
µL saline) and three positive control eyes (30 µL Benzalkonium Chloride
(BAC)) were tested. After the exposure the eyes were rinsed with 20 mL
saline and were examined at approximately 0, 30, 75, 120, 180, and 240
minutes after treatment. The test substance caused very slight corneal
swelling (4%), very slight or slight opacity (mean score of 0.7) and no
fluorescein retention (mean score of 0.0). The negative control eye did
not show any corneal effect and demonstrated that the general conditions
during the tests were adequate. The positive control BAC 5% caused
severe corneal effects and demonstrated the ICE test valid to detect
severe eye irritants. Microscopic examination of the corneas treated
with Pinyl Iso Butyraldehyde revealed very slight erosion (two corneas)
and slight necrosis (one cornea) of the epithelium. Microscopic
examination of the cornea treated with the negative control (saline) did
not reveal any abnormalities, apart from very slight vacuolation (top
region) of the epithelium. The positive control BAC 5% caused moderate
or severe erosion, slight vacuolation (one cornea; low region) of the
epithelium, and endothelial necrosis. Based on these results the test
substance is not considered to be an eye irritant.
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