Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 251-718-8
CAS number: 33885-52-8
Air: Based on estimation with the QSAR model Aopwin the substance
undergoes in air rapid degradation after reaction with hydroxyl radicals
and ozone. The DT50 value after reaction with hydroxyl radicals is 1.11
hours and for ozone it was estimated 38.4 minutes. Based on these
half-lives, the substance will not reach the stratosphere and is
therefore not considered to be a long-range transported chemical in air.
The substance does not have an ozone depletion potential because it does
not contain halogens and does not have the potential to reach the
stratosphere (EU CLP, EC no 1272/2008 and its amendments).
Water: The substance is hydrolytically stable in an OECD TG 111
study at pH 4, 7 and 9 at 25°C (DT50> 1 year).
In the key GLP Closed Bottle test (OECD TG 301D) secondary activated
sludge was exposed to 2 mg/l substance for 28 days. In this test 3%
biodegradation was observed at day 28. Therefore the substance is not
readily biodegradable. In the follow up enhanced test (Closed Bottle,
non-GLP) with river water as inoculum at 1 mg/L, 73% biodegradation was
found after 56 days showing that the substance is not persistent in
accordance with ECHA guidance (R.11 -3, 2017). In a MITI test (OECDTG
301C) the substance is not biodegraded but full primary degradation
occurred the key metabolites being the Pinyl Isobutyr-acid and Pinyl
Isobutyr-alcohol, the oxidation and reduction product of Pinyl
The bioaccumulation potential for aquatic species was concluded based on
an experimental BCF for fish performed according to a Japanese guideline
and under GLP, equivalent to OECD TG 305. The BCF was concluded < 27
L/kg ww, indicating no potential for bioaccumulation.
Bioaccumulation result for terrestrial species is based on log Kow and
calculated BCF value using QSAR of Jager (1998), incorporated in the
EUSES model yielded a value of 3020 L/kg ww. This value is considered
conservative because the substance likely oxidises into the acid under
environmental circumstances and the absence of a bioaccumulation
potential in fish.
Transport and distribution
The adsorption potential of the substance was determined in a
study according to OECD TG 121 (HPLC method). Under the conditions of
the test, the log Koc of the substance was determined at 4.07
(equivalent Koc = 12000 L/kg). Based on this value the substance has
potential for adsorption to solid surfaces and soil.
A Henry's law constant of 36.6 Pa·m³/mol (at 12 °C) was
calculated in EUSES (Vap pressure 3.4 Pa (22°C) , 206.29 molecular
weight and 10.8 mg/l water solubility (22°C). Based on this value the
substance has potential to partition from water to air.
Based on Level III environmental distribution modelling using
EPISUITE (assuming equal and continuous releases to air, water and soil)
using the CAS number 33885-52-8 and the measured physico-chemical
parameters (water solubility and log Kow) as input , it is estimated
that the majority of the substance released to the environment will
partition mainly into soil (83.8%) and water (15.8%) with small amounts
to air (0.1%) and sediment (0.3%).
The SimpleTreat model simulates the distribution of the substance in
a Sewage Treatment Plant. Model calculations (default assumptions,
local) show that 0% of the substance will be degraded and that 30.5%,
53.2%, and 16.3% will partition to water, sludge and air, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again