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EC number: 259-134-5
CAS number: 54381-16-7
1: Eye irritation observations (Study # 6A050)
Days after instillation
Area of corneal opacity
purpose of this in-vivo eye irritation test was to evaluate eye
irritation potential of N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine
Sulfate when applied once to rabbit eye.
rabbits (2 male and 4 female) were used in the study. The 100 mg test
substance was applied to the left eye of each rabbit. The test substance
was not removed after treatment.
animals were observed for signs of corneal opacity, iris irritation,
conjuctivae redness, lid swelling and discharge on Day 1-4 of study.
signs of irritation were observed on Day 1-4 after treatment.
on above, N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate was found
to be irritating when instilled undiluted (without eye rinse) to
rabbit’s eye. According to CLP criteria, the
registered substance was classified as Category 1 for eye irritation.
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