Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-03-25 to 2010-03-31
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study completed according to Directive 92/69/EC method A.8 (1992) and OECD test procedure 107 (shake flask method).
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Remarks:
Included in study report
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
-2.8
Temp.:
20 °C
pH:
4

Buffer Phases

  Buffer phase to 100mL water  Determined conc of test item/mg/100mL)   Conc of test item related to 1g buffer phase 
1.9987  5.300  2.651 
2.1064  5.556  2.637 
2.0380  5.410  2.655 
1.9840  5.262  2.652 
2.0097  5.337  2.656 
2.0380  5.402  2.651 

Octanol phases

  Octanol phase extracted to 10mL water  Extraction volume of water/mL  Determined conc of test item/(mg/100mL)   Determined conc related to extraction volume/ (mg/2mL resp 5mL)   Conc of test item (mg related to 1 g of octanol phase) 
3.0117  0.656  0.0131  0.0044 
3.2042  0.665  0.0133  0.0042 
7.3552  0.634  0.0317  0.0043 
6.9915  0.586  0.0293  0.0042 
14.332  1.133  0.0567  0.0040 
14.224  1.181  0.0591  0.0042 

Calculation of Pow and log Pow

  Pow (10 -3)  log Pow  Average Pow (10 -3)  Average log Pow 
1.660  -2.780  1.627  -2.789 
1.593  -2.798     
1.620  -2.791  1.602  -2.796 
1.584  -2.800     
1.506  -2.822  1.545  -2.811 
1.584  -2.800     

Conclusions:
The partition coefficient of N,N-bis(2-hydroxyethyl)-p-phenylenediamine sulphate monohydrate was determined according to a test procedure which complies with EU test method L383 A/63-73 (EU A.8) and related OECD test procedure 107 (shake flask method). The partition coefficient (log Pow) was determined to be -2.80.
Executive summary:

The partition coefficient (n-octanol/water) of N,N-bis(2 -hydroxyethyl)-p-phenylenediamine sulphate was determined according to a test procedure which complies with EU test method L383 A/63 -73 (EU A.8) and related OECD test procedures 107 (shake flask method). The partition coefficient (log Pow) was determined to be -2.80.

Description of key information

The partition coefficient of N,N-bis(2 -hydroxyethyl)-p-phenylenediamine sulphate monohydrate was determined according to a test procedure which complies with EU test method L383 A/63-73 (EU A.8) and related OECD test procedure 107 (shake flask method). The partition coefficient (log Pow) was determined to be -2.80.

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.8
at the temperature of:
20 °C

Additional information

The partition coefficient (n-octanol/water) of N,N-bis(2 -hydroxyethyl)-p-phenylenediamine sulphate was determined according to a test procedure which complies with EU test method L383 A/63 -73 (EU A.8) and related OECD test procedures 107 (shake flask method). The partition coefficient (log Pow) was determined to be -2.80.