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EC number: 259-134-5
CAS number: 54381-16-7
The acute toxicity of 2-[[(4-aminophenyl)-(2-hydroxyethyl)]amino]ethanol
sulphate on aquatic organisms was determined on the 3 trophic levels
(Fish, daphnids and algae) according to OECD guidelines and following
- 96h LC50 on Zebrafish > 235 mg/L, based on measured concentrations and
according to OECD 236;
- 48h EC50 on Daphnia magna = 0.381 mg/L, based on measured
concentrations and according to OECD 202;
- 72h EC50 (growth rate) on Pseudokirchneriella subcapitata = 0.338 mg/l
based on measured concentrations and according to OECD 201;
The chronic toxicicity was assessed on daphnia and algae :
- 21d-NOEC reproduction = 0.674 mg/L based on mean measured
concentrations and according to the OECD 211;
- 72h-EC10 growth rate = 0.272 mg/l based on mean measured
concentrations and according to the OECD 201.
- 3h-IC50 sludge respiration = 228 mg/L based on nominal concentrations
and according to OECD 209.
The Fish is the less sentitive species to this substance. The algae test
is the most sensitive test with a ErC10 = 0.272 mg/L and this value has
to be chosen for the PNEC calculation.
The comparison between the acute and chronic results obtained on the
same species shows a low difference for algae, and the NOEC is even
higher than the EC50 for daphnia. However the chronic test on Daphnia is
considered more relevant than the acute test due to :
- an extended period of exposure to the substance (21days versus
- the parameters taken into account (only immobility in acute test
and immobility and reproduction in chronic test),
- the flow-through conditions in the chronic test with relative
stable concentrations compared to semi-static conditions in acute test
where the tested concentrations decrease during 24 hours (period before
the medium renewal).
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