Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 259-134-5
CAS number: 54381-16-7
Substance Log k'Values
R2 = 0.9054 ;Slope=1.767 ;
Intercept = 1.7482
of Log Koc for
Test subst. Retention time (min.)
Test Mix 2
Mean log Koc
The Adsorption Coefficient of
2-[[(4-aminophenyl)-(2-hydroxyethyl)]amino]ethanol sulphate was
determined following OECD 121 (High Performance Liquid Chromatography
(HPLC)) and under GLP. The Koc of the tested substance was determined
through comparison to compounds with known Koc values based upon the
retention times on an HPLC analytical column.
A solution containing the tested substance and thiourea (an unretained
organic compound used to establish dead time) was prepared and analyzed
on a liquid-phase chromatograph equipped with a UV detector, a column
heater set at 25 °C, and an analytical column packed with cyanopropyl
4-nitrobenzamide, atrazine, N,N-dimethylbenzamide, naphthalene,
phenanthrene, and phenol were used as reference substances and analyzed
under the same analytical conditions. Samples of the tested substance
were analyzed in duplicate and the standard mix of the reference
substances was injected before and after the tested substance and
thiourea. The measured retention times (consistent with those listed in
the guidelines) and literature documented Koc values of the reference
substances were used to construct a calibration graph. The Koc value of
the tested substance was then determined using the calibration curve.
All the validity criteria are met, except that there were no reference
compounds that eluted before the tested substance and the Koc is
extrapolated. However it was considered that the determination of the
Koc by this method was consistent with low adsorbing compounds as
estimated from the linear response of the reference substances used.
At 25 °C, the log of the adsorption coefficient of 2 -[[(4
-aminophenyl)-(2 -hydroxyethyl)]amino]ethanol sulphate to soil was
determined to be 0.63 (Koc = 4.3 L/kg) by HPLC estimation method.
The Adsorption Coefficient, log KOC, of
2-[[(4-aminophenyl)-(2-hydroxyethyl)]amino]ethanol sulphate, for soil
was 0.63 (Koc 4.3 L/kg) measured by HPLC method (OECD 121).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again