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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data s from peer- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs
Author:
D. L. J. Opdyke
Year:
1978
Bibliographic source:
Food and Cosmetics Toxicology

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Acute dermal toxicity study of test chemical in rabbit.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Citronellyl isobutyrate
- IUPAC name: 3, 7-dimethyloct-6-en-1-yl 2-methylpropanoate
- Molecular formula: C14H26O2
- Molecular weight: 226.3574 g/mol
- Substance type: Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
5000 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in treated rat at 5000 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be > 5000 mg/kg bw when rabbits were treated with test chemical dermally.
Executive summary:

In acute dermal toxicity study, rabbits were treated with test chemical in the concentration of 5000 mg/kg bw orally. No mortality was observed at 5000 mg/kg bw in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg bw when rabbits were treated with test chemical dermally.