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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Principles of method if other than guideline:
To determine Partition coefficient (Pow) on soil and on sewage sludge of the test chemical using HPLC.
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
5.415
Temp.:
25 °C
pH:
6.15
Remarks on result:
other: The log octanol-water Partition coefficient is 5.4148 ± 0.0063

Test substance

K

LogK

Log Pow by Generalized Calibration Graph

Mean of logPow ± S.D

Tr1

9.353

8.9468

0.9517

5.4103

5.4148 ± 0.0063

Tr2

9.42

9.0181

0.9551

5.4192

Conclusions:
The partition coefficient (n-octanol/water) of test substance 3,7-dimethyloct-6-enyl isobutyrate was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 5.4148 ± 0.0063 dimensionless at 25°C.
Executive summary:

The partition Coefficient n-octanol/water of test chemical 3,7-dimethyloct-6-enyl isobutyrate was determined by the Reverse Phase High Performance Liquid Chromatography method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to the estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 0.5 to 4.6. The Log Pow value was determined to be 5.4148 ± 0.0063 at 25°C.This value indicates that the substance is very hydrophobic in nature.

Description of key information

The partition coefficient (n-octanol/water) of test substance 3,7-dimethyloct-6-enyl isobutyrate was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 5.4148 ± 0.0063 dimensionless at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
5.415
at the temperature of:
25 °C

Additional information

The partition Coefficient n-octanol/water of test chemical 3,7-dimethyloct-6-enyl isobutyrate was determined by the Reverse Phase High Performance Liquid Chromatography method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to the estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 0.5 to 4.6. The Log Pow value was determined to be 5.4148 ± 0.0063 at 25°C.This value indicates that the substance is very hydrophobic in nature.