Registration Dossier
Registration Dossier
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EC number: 601-818-6 | CAS number: 122009-11-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In a bacterial mutagenicity test, performed according to OECD guideline 471, four Salmonella typhimurium strains (TA 1535, TA 1537, TA 98, and TA 100) were used to test the mutagenic potential of the test substance both with and without metabolic activation (BASF 1989). One standard plate test and one preincubation test were performed. In both tests strains were exposed to 0, 20, 100, 500, 2500 and 5000 µg/plate. No precipitation of the test substance was found. No bacteriotoxic effect was observed. An increased number of his+ revertants was not observed in the standard plate test or in the preincubation test either without S9 mix of after the addition of a metabolizing system. It was therefore concluded that the test substance is not mutagenic under these experimental conditions.
Justification for selection of genetic toxicity endpoint
One genetic toxicity in vitro study is available. This study is adequate for covering this endpoint.
Short description of key information:
It is concluded that there is no evidence of induction of gene mutations by the test substance and its metabolites in the four S. typhimurium strains used in an OECD 471 guideline study.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
2-Butenoic acid, 4-(diethoxyphosphinyl)-2-methyl-, ethyl ester is non-mutagenic in a bacterial reverse mutation assay. Therefore classification in accordance with EU Directive 67/548 (DSD) and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008 is not warranted.
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