Registration Dossier
Registration Dossier
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EC number: 601-818-6 | CAS number: 122009-11-4
Endpoint summary
Administrative data
Description of key information
In two acute oral toxicity, the LD50 was determined to be >2000 mg/kg bw. Exposure for 8 hours to the saturated vapour pressure did not result in adverse effects.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity
Two studies were performed in which five Wistar rats per sex per dose were exposed to the test substance dissolved in 0.5% aquaous carboxymethyl cellulose solution, via oral gavage. In study 1 (BASF1989) animals were exposed to 2000 mg/kg bw, and in study 2 (BASF1976) animals were exposed to 3476, 5104, 7480 and 11000 mg/kg bw. After an observation period of 14 days the surviving animals were necropsied. Several clinical signs were observed (dyspnea, apathy, prone/lateral position, staggering, atonia, loss of pain reflex, partial loss of corneal reflex, twitching, salivation, and poor general state). In study 2 pathological changes in the heart, glandular stomach and small intestine were also observed. The LD50 was determined to be >2000 mg/kg bw in study 1 and between 3476 and 5104 mg/kg bw in study 2.
Acute inhalation toxicity
Six rats per sex were exposed to the saturated vapour (0.09 mg/L air) of the test substance. After an observation period of 7 days, animals were necropsied. No clinical signs, pathological effects or mortality was observed in all exposed animals. No hazard could be identified because the exposure level tested was to low.
Justification for selection of acute toxicity – oral endpoint
Two studies acute oral toxicity studies are available. The most detailed study was chosen as key.
Justification for selection of acute toxicity – inhalation endpoint
Only study available
Justification for classification or non-classification
Based on an oral LD50 of >2000 mg/kg bw classification for acute oral toxicity is not warranted in accordance with Directive 67/548/EEC (DSD) and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
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