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EC number: 294-409-3
CAS number: 91722-09-7
Substance formed during processing of liquid steel or during production of iron castings. Consists primarily of fused silicates and trace elements as oxides as well as trace of alloying elements.
mutation in bacteria/mammalian/ and cytogenicity or micronucleus
formation refers to the ability of a substance to change and/or disrupt
the genetic material (DNA) of bacteria/mammals/mammalian cells. If
there is a positive result, the substance may cause gene mutagen in
bacteria, mammals, cytogenicity or formation in mammalian cells of a
micronucleus. It may also impact the genetic material in humans which in
turn could lead to the development of cancer, affect reproduction or
lead to an adverse health effect in offspring.
there is a positive result in one or more in vitro tests, further
mutagenicity studies in vivo must be considered to assess these
types of effects, the possible concern for effects in humans needs to be
further assessed in a living animal test system.In vivomutagenicity
refers to the ability of a substance to damage the genetic material
(DNA) of living mammals.
reproductive and/or developmental toxic substance may affect fertility
and can cause health effects in offspring after recurring contact.
The exposure can occur by ingestion, inhalation, or skin contact.
a substance is a reproductive and/or developmental toxicant, it may
induce fertility problems, problems with the ability to reproduce and
serious health effects in the offspring. A screening test for
reproduction/developmental toxicity gives a first impression of possible
problems with the ability to reproduce.
available test results from following studies (in
vitro and in vivo) are all negative:
The negative test results
indicate there are no potential to induce damages/changes in the genetic
material (DNA) of living mammals.
The exposures by
ingestion and skin contact are considered as negligible (see further
information in endpoint 7.2 and 7.3) and are not critical and/or
relevant for this endpoint.
The exposure by
inhalation was assessed as not acute toxic, supported by the test
results from performed acute and short-term repeated inhalations
Based on previous scientific considerations, no
further testing for screening test for reproduction/developmental
toxicity is required.
For further discussion, summary and test result for each endpoint below,
kindly see the link (linked study/endpoint records) in Cross reference
under Administrative data
Acute toxicity (oral, dermal and inhalation)
No acute toxicity of any routes, based on the conclusion of the
following test results:
Oral: ABS, GBS, EAF C: OECD TG 401, rats: LD50 > 2000 mg/kg bw, BOS,
SMS: OECD TG 423, rats: LD50 > 2000 mg/kg bw.
Inhalation: GGBS: OECD 403, rats: 4 h-LC50 >5235 mg/m³
Skin: BOS, SMS: rats OECD 402, rats: LD50 > 4000 mg/kg
Additional information (ABS): equal to oral intake. Slag leachtest
fulfil the quality criteria of the German Federal Drinking Water
Regulation. Conclusion: pose no risk to human health, when the criteria
for drinking water is fullfil.
Several in vitro and in vivo tests on ferrous slags demonstrate that
these slags have no irritant and no corrosive potential to skin and eye.
From dermal toxicity testing with BOS and SMS, it is concluded, that no
components of these UVCBs are taken up at relevant concentrations
through the skin. Therefore this absorption of ferrous slag through the
skin can be neglected including toxicokinetics.
ABS, EAF C, and EAF S are not sensitising when tested according to OECD
406 and NF EN ISO 10993-10 (February 2003) concerning biological
evaluation of medical devices: Tests for irritation and delayed-type
hypersensitivity. BOS and SMS are not sensitising when tested according
to OECD TG 406 Skin Sensitisation Test.
There is no indication of carcinogenic potential of ferrous slags based
on available data from literature.
Ferrous slags do not have any mutagenic potential and/or change/disrupt
the DNA of bacteria and mammalian cells, assessed by the negative test
results, performed by OECD 471, OECD 474 and OECD 476.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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