Slags, steelmaking, converter

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2004-2006

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study with acceptable restrictions

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

2006

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

2007

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Slags, steelmaking, converter

EC Number:

294-409-3

EC Name:

Slags, steelmaking, converter

Cas Number:

91722-09-7

Molecular formula:

~ Al(n)Ca(m)Fe(o)Mg(p)Mn(q)Si(r)O(3n/2+m+o+p+q+2r)

IUPAC Name:

Aluminium-Calcium-Iron-Magnesium-Manganese-Silicium oxide equivalent

Details on test material:

In order to substantiate this evaluation, the Tecarn-Tecnologia Ambiental Ltda accredited before the Ministry of Agriculture and is holder of bio-safety certificates.
BOS samples were collected in CST´s processing plants. The crushed stone is from Brasitalia quarry, located in the municipality of Serra, Brasilia. Crushed stone samples were collected and prepared by the company Kaerne Engenharia Ltda. In compliance with the method defined in NBR 10.007.2007.

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

In the case of products mortality was not observed with the minimum dosage DL50 will be considered as higher than 2000 mg/kg.

No. of animals per sex per dose:

3

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: highest and only concentration tested

Mortality:

none observed

Clinical signs:

other: none reported

Gross pathology:

not reported

Other findings:

none reported

Any other information on results incl. tables

BOS: LD₅₀> 2000 mg/kg

Crushed stone: LD₅₀> 2000 mg/kg

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

BOS: OECD 423 rat: LD50 > 2000 mg/kg
Crushed stone: LD50 > 2000 mg/kg

Executive summary:

To examine the oral toxicity of slags, steelmaking, converter (BOS) and crushed stone from a quarry in the vicinity of Serra, Brasilia, tests were performed following OECD guideline 423 in Wistar rats. Fine-ground BOS and crushed stone were dosed by gavage, in their original form, at 2 g/kg bw (body weight). After dosing, the animals were observed for a post exposure period of 14 days. The LD₅₀ was > 2000 mg/kg bw for each test material.

Slags, steelmaking, converter (BOS) and natural stone from a quarry in Serra, Brasilia, are not toxic via the oral route,and do not need to be classified as oral toxicants. No signal word and no hazard statement is required.