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EC number: 294-409-3
CAS number: 91722-09-7
Substance formed during processing of liquid steel or during production of iron castings. Consists primarily of fused silicates and trace elements as oxides as well as trace of alloying elements.
Results of main experiment (cultures without likelyhood of effect were
To investigate the cytotoxic and mutagenic potential of ferrous slags, a
test according to the EU Method B.17 (Mutagenicity - In Vitro Mammalian
Cell Gene Mutation Test) was performed with slags, ferrous metal, blast
furnace (air cooled - ABS), granular (8-11 mm). The investigation tests
the potential of the slag applied as DIN 38414 S4 leachates, to induce
gene mutations at the HPRT locus in V79 cells of the Chinese hamster.
Two independent experiments were performed, using two parallel cultures
each. The first main experiment was performed with and without liver
microsomal activation and a treatment period of 4 hours. The second
experiment was performed with a treatment time of 4 hours with and 24
hours without metabolic activation, up to 10 % v/v of the undiluted
extract being the maximum possible concentration of aqueous extracts in
the HPRT test system.
No substantial and reproducible dose dependent increase of the mutation
frequency was observed in all experiments. The sensitivity of the test
system, and the effectiveness of the metabolic activation system, was
confirmed by tests with reference mutagens, used as positive controls.
Slags, ferrous metal, blast furnace (air cooled - ABS), granular (8-11
mm) did not induce gene mutations at the HPRT locus in V79 cells. Slags
are neither cytotoxic nor mutagenic under the conditions of the HPRT
(Hypoxanthin-Guanin-Phosphoribosyltransferase) gene mutation test
according to EU 440/2008 B.17.
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