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EC number: 218-414-7
CAS number: 2146-71-6
Vinyl laurate was tested in the Micronucleus test in mice according to
OECD Guideline 474. The test item used was a colourless liquid with a
purity of 99%. The test substance was dissolved in corn oil and was
administered via oral gavage. In a dose range finding study 6 animals (3
males and 3 females) were dosed with 2000 mg/kg bw, the highest dose
requested by the OECD guideline. All animals showed no abnormalities
In the main study, five animals were used in each of six treatment
groups, including negative and positive controls. All groups received a
single oral intubation. The negative and positive control groups were
treated with vehicle and 50 mg/kg bw cyclophosphamide respecitvely.
Animals were dosed with the test item Vinyl laurate at 2000 mg/kg bw
(two groups), 1000 (one group) and 500 (one group) mg/kg body weight.
All animals showed no abnormalities after dosing.
Bone marrow of the groups treated with Vinyl laurate was sampled 24 and
48 (highest dose only)hours after dosing. No increase in the mean
frequency of micronucleated polychromatic erythrocytes was observed in
the polychromatic erythrocytes of the bone marrow of animals treated
with Vinyl laurate.
The incidence of micronucleated polychromatic erythrocytes in the bone
marrow of all negative control animals was within the historicl solvent
control data range. Cyclophospamid, the positive control substance,
induced a statistically significant increase in the number of
micronucleated polychromatic erythrocytes. Hence, both criteria for an
acceptable assay were met.
The groups that were treated with Vinyl laurate showed no decrease in
the ratio of polychromatic to normochromatic erythrocytes compared to
the vehicle controls, which reflects a lack of toxic effects of this
compound on the erythropoiesis. The groups that were treated with
cyclophosphamide showed an expected decrease in the ratio of
polychromatic to normochromatic erythrocytes compared to the vehicle
controls, demonstrating toxic effects on erythropoiesis.
It is concluded that Vinyl laurate is not clastogenic in the
micronucleus test under the experimental conditions described in the
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