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EC number: 218-414-7
CAS number: 2146-71-6
The effects of Vinyl laurate on the possible health hazards likely
to arise from repeated exposure over a relatively limited period of time
were assessed in a OECD 422 study. . In addition this combined repeated
dose toxicity study with the reproduction/developmental toxicity
screening test in the Han Wistar rat provides information on possible
effects on male and female reproductive performance such as gonadal
function, mating behavior, conception, development of the conceptus and
Vinyl laurate was administered to male rats for at least 28 days
and to female rats for 14 days prior to pairing, through the pairing and
gestation periods until the F1 generation reached day 4 post partum. The
following dose levels were applied:
Group 1: 0 mg/kg body weight/day (control group), Group 2: 50
mg/kg body weight/day, Group 3: 250 mg/kg body weight/day, Group 4: 1000
mg/kg body weight/day. A standard dose volume of 5 mL/kg body weight
with a daily adjustment to the actual body weight was used. Control
animals were dosed with the vehicle alone (corn oil).
All parent animals survived until the scheduled necropsy. No
clinical signs or observations were noted for any male or female in any
groups during the duration of the study. No test item-related findings
were noted in the Functional Observational Battery. Mean food
consumption and body weights were note affected by treatment with the
test item in the males and females during the study. No test
item-related effects were noted from the clinical laboratory
investigations. All female mated. No effects were noted in the
reproduction and breeding data. No test item-related effects were noted
in the organ weights. No test item-related macroscopical or
histopathological findings were observed.
No test item-related findings at first litter check and during
lactation were noted. Pup weights to day 4 post partumwere unaffected by
treatment with the test item. No test item-related macroscopical
findings were observed in the pups. .
The general NOEL (No Observed Effect Level) was considered to be
1000 mg/kg body weight/day.
The NOEL (No Observed Effect Level) for reproduction/developmental
toxicity was also considered to be1000 mg/kg body weight/day.
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