Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-414-7
CAS number: 2146-71-6
The effects of Vinyl laurate on the possible health hazards likely to
arise from repeated exposure over a relatively limited period of time
were assessed in a OECD 422 study. . In addition this combined repeated
dose toxicity study with the reproduction/developmental toxicity
screening test in the Han Wistar rat provides information on possible
effects on male and female reproductive performance such as gonadal
function, mating behavior, conception, development of the conceptus and
Vinyl laurate was administered to male rats for at least 28 days and to
female rats for 14 days prior to pairing, through the pairing and
gestation periods until the F1 generation reached day 4 post partum. The
following dose levels were applied:
Group 1: 0 mg/kg body weight/day (control group), Group 2: 50 mg/kg body
weight/day, Group 3: 250 mg/kg body weight/day, Group 4: 1000 mg/kg body
weight/day. A standard dose volume of 5 mL/kg body weight with a daily
adjustment to the actual body weight was used. Control animals were
dosed with the vehicle alone (corn oil).
All parent animals survived until the scheduled necropsy. No clinical
signs or observations were noted for any male or female in any groups
during the duration of the study. No test item-related findings were
noted in the Functional Observational Battery. Mean food consumption and
body weights were note affected by treatment with the test item in the
males and females during the study. No test item-related effects were
noted from the clinical laboratory investigations. All female mated. No
effects were noted in the reproduction and breeding data. No test
item-related effects were noted in the organ weights. No test
item-related macroscopical or histopathological findings were observed.
No test item-related findings at first litter check and during lactation
were noted. Pup weights to day 4 post partumwere unaffected by treatment
with the test item. No test item-related macroscopical findings were
observed in the pups. .
The general NOEL (No Observed Effect Level) was considered to be 1000
mg/kg body weight/day.
The NOEL (No Observed Effect Level) for reproduction/developmental
toxicity was also considered to be1000 mg/kg body weight/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again