Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-414-7 | CAS number: 2146-71-6
Endpoint summary
Administrative data
Description of key information
No toxicity was observed bot after oral and dermal adminbistration of vinyl laurate up to the highest requested dose of 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
A group of five male and five female Sprague-Dawley rats was treated with Vinyl laurate at 2000 mg/kg by oral gavage according to OECD Guideline 401 with a 14 days observation period. No animal died during the study. No signs of toxicity were not observed in any animal. The body weight of the animals was within the range of physiological variability known for rats of this strain and age. No macroscopic findings were observed at necropsy of the animals. The LD50 (oral, rat) was determined to be > 2000 mg/kg bw.
A group of five male and five female Wistar rats was treated with Vinyl laurate at 2000 mg/kg by single dermal application according to OECD Guideline 402 with a 14 days observation period. One animal died during the first day after application. Only slight signs of toxicity were not observed in the surviving animals like flat/hunched posture, piloerection Diarrhea, chromodacryorrhoea (snout) and/or ptosis. The animals recovered from the symptoms between day 2 and 4 of the study. Scales and scrabs were seen in the treated skin area of several animals during the observation period. The body weight of the animals was within the range of physiological variability known for rats of this strain and age. No macroscopic findings were observed at necropsy of the animals. The LD50 (dermal, rat) was determined to be > 2000 mg/kg bw.
Justification for classification or non-classification
As there was no effect in both dermal and oral administration of the test item, no classification is necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
