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EC number: 218-414-7
CAS number: 2146-71-6
No toxicity was observed bot after oral and dermal adminbistration of vinyl laurate up to the highest requested dose of 2000 mg/kg bw.
A group of five male and five female Sprague-Dawley rats was treated
with Vinyl laurate at 2000 mg/kg by oral gavage according to OECD
Guideline 401 with a 14 days observation period. No animal died during
the study. No signs of toxicity were not observed in any animal. The
body weight of the animals was within the range of physiological
variability known for rats of this strain and age. No macroscopic
findings were observed at necropsy of the animals. The LD50 (oral, rat)
was determined to be > 2000 mg/kg bw.
A group of five male and five female Wistar rats was treated with Vinyl
laurate at 2000 mg/kg by single dermal application according to OECD
Guideline 402 with a 14 days observation period. One animal died during
the first day after application. Only slight signs of toxicity were not
observed in the surviving animals like flat/hunched posture,
piloerection Diarrhea, chromodacryorrhoea (snout) and/or ptosis. The
animals recovered from the symptoms between day 2 and 4 of the study.
Scales and scrabs were seen in the treated skin area of several animals
during the observation period. The body weight of the animals was within
the range of physiological variability known for rats of this strain and
age. No macroscopic findings were observed at necropsy of the animals.
The LD50 (dermal, rat) was determined to be > 2000 mg/kg bw.
As there was no effect in both dermal and oral administration of the
test item, no classification is necessary.
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