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EC number: 218-414-7
CAS number: 2146-71-6
A Local Lymph Node Assay according to OECD 429 has been performed with
Vinyl laurate. Test substance concentrations selected for the main study
were based on the results of a preliminary study. In the main study,
three groups of five experimental animals were treated with test
substance concentrations of 10, 25 and 50 % on three consecutive days by
open application on the ears. Five vehicle control animals were
similarly treated but with vehicle alone (acetone/olive oil). Three days
after the last exposure all animals were injected with 3H-methyl
thymidine and after five hours the draining (auricular) lymph nodes were
After precipitating the DNA of the lymph node cells, radioactivity
measurements were performed. The activity was expressed as the number of
Desintegrations Per Minute (DPM) and a stimulation index was
subsequently calculated for each group.
Skin irritation was observed in the animals examined. The higher dose
groups showed more severe skin irritation. The irritation of the ears as
shown by the animals was considered not to have a toxicologically
significant effect on the activity of the nodes.
All nodes of the experimantal and control groups were considered normal
in size. No macroscopic abnormalities of the surrounding area were
noted. Mean DPM/animal values for the experimental groups treated with
test substance concentrations 10, 25 and 50 % were 231, 400 and 501
respectively. The mean DPM/animal value for the vehicle control was 304.
The Stimulation indicees (SI) for the substance concentrations 10, 25
and 50% were 0.8, 1.3 and 1.6 respectively.
Since there was no indication that the test substance could elicit an SI
>= 3 when tested up to 50% it was established that the EC3value (if any)
The six months reliability check with hexylcinnamic aldehyde indicates
that the Local Lymph Node Assay as performed by the testing facility is
an appropriate model for testing for contact hypersensitivity.
Based on the results according to the EU criteria for classification and
labeling requirements Vinyl laurate does not have to be classified and
has no obligatory labeling requirement for sensitization by skin contact.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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