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EC number: 204-677-5
CAS number: 124-07-2
Octanoic acid (CAS 124-07-2) has a log Kow of 3.05 (HSDB by Hansch
et al. 1995) and a log Koc of 2.05 (ChemProp v6.4, Franco, Fu & Trapp
model for ionizable substances, estimated from log Kow of 3.05, pKa of
5.3 and pH 7). Thus, the potential to adsorb or bind onto soil particles
is expected to be low. In addition, Octanoic acid (CAS 124-07-2) show no
indication that the substance is very toxic, as the EC/LC50 values are >
1 mg/L for algae, daphnia or fish. Thus, according to the Guidance on
information requirements and chemical safety assessment, R.7c (ECHA,
2017) Octanoic acid (CAS 124-07-2) is in the soil hazard category 1
which requires a screening assessment of PEC/PNECscreen based on the
equilibrium partitioning method (EPM). As the environmental exposure
assessment based on a screening PNEC soil (Derived by Equilibrium
Partitioning Method (EPM)) indicates no risk for the soil compartment
(Risk Characterisation Ratio (RCR) < 1; please refer to Chapter 9 and 10
of the Chemical Safety Report for detailed information), no risk for the
soil compartment is indicated.
In addition, the substance is determined to be readily
biodegradable and according to the Guidance on information requirements
and chemical safety assessment, Chapter R.7b (ECHA, 2017), readily
biodegradable substances can be expected to undergo rapid and ultimate
degradation in most environments, including biological Sewage Treatment
Plants (STPs). Therefore, this substance has a low potential for
persistence and chronic exposure of sediment organisms is unlikely.
Further degradation studies cited in the Draft Assessment Report (DAR)
for Fatty Acids (C7-C20) (Volume1, 2008) DT50 values of 1.5 to 3 days
were reported, indicating rapid primary degradation of fatty acids by
microbial organisms in the soil .
Moreover, in the Draft Assessment Report (DAR) for Fatty Acids
(C7-C20) (Volume 1, 2008) low toxicity of a fatty acid formulation was
demonstrated in several tests on soil macroorganisms, terrestrial
non-target arthropods and terrestrial plants. These studies prove the
negligible effects of fatty acids to terrestrial macroorganisms.
Furthermore, fatty acids occur in sediment and soils naturally and are
part of physiological pathways. Fatty acids are used by soil organisms
as an energy source and for anabolic processes as well. In anabolic
processes fatty acid carbon is incorporated into the biological matrix
of the organism. The suitability as an energy source was demonstrated by
the ready biodegradability of the substance, which is used from
microorganisms as energy source by degrading the substance to carbon
dioxide. Moreover, the bioaccumulation potential of Octanoic acid (CAS
124-07-2) is expected to be low i.e. based on log D of 1.34 (pH 7),
metabolisation and excretion processes and low BCF values of 225 L/kg
after 28 days (OECD 305 E, 1999) from a read-across substance and 83.64
L/kg (EPISuite, BCFBAF, Arnot-Gobas model) based on QSAR. Overall, fatty
acids are generally not considered to be harmful either to soil
organisms. Hence, in case of exposure to soil, the substance is expected
to rapidly dissipate either by degradation or by integration into the
organism matrix. Therefore soil is not expected to be a compartment of
concern and the risk to soil organisms is negligible.
According to the Guidance on information requirements and chemical
safety assessment, Chapter R.7c (ECHA, 2017), when the substance is
readily biodegradable and has a log Kow < 5, the screening assessment
showing no risk using aquatic toxicity data (RCR < 1) is sufficient to
obviate the need for further information. In addition, low toxicity of a
fatty acid formulation was observed in several tests on soil
macroorganisms and fatty acids are used by soil organisms as an energy
source. Therefore, no soil toxicity tests are needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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