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EC number: 204-677-5
CAS number: 124-07-2
Readily biodegradable: >72% after 30 d (OECD 301D, non GLP)
Three studies on the ready biodegradability of octanoic acid are
The first study (2004) was performed according to OECD 301D (non
GLP) where octanoic acid was tested at concentrations of 2 and 5 mg/L
for 30 days. At the test substance concentration of 5 mg/L more than 72%
was degraded within 30 days. Due to the good biodegradability, the
oxygen concentration at 5 mg/L remained inadequate so that the 72%
should be regarded as a minimum value. At test concentration of 2 mg/L
octanoic acid was completely degraded while 60% degradation was reached
within the 10-day window, as required. Thus, the test substance can be
regarded as readily biodegradable. This study was chosen as the key
study, since the direct application of the test substance was most
appropriate in this OECD 301D test and the validity criteria were met.
In the first supporting study (1988) octanoic acid was assessed
according to OECD 301B (modified Sturm Test, GLP). The test substance
was added to the flasks adsorbed at charcoal particles. This guideline
deviation probably reduced the availability of the test substance to the
microorganisms. Nevertheless, the results revealed a degradation of
51.6% - 54.4% clearly indicating the biodegradation potential of
The ready biodegradability is supported by another OECD 301B test
(1991) performed under GLP conditions where octanoic acid was directly
added at two concentrations (10 and 20 mg/L). The result showed a
degradation of 68% and 70% for 10 mg/L and 20 mg/L, respectively.
Moreover, octanoic acid met the criteria for ready biodegradation (10-d
window) in the lower concentration. Since the reference substance did
not meet the current validity criteria (degradation of 60% within 10
days), the test results have to be interpreted with caution.
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