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EC number: 204-677-5
CAS number: 124-07-2
Exposure concentrations and the estimated water solubility of laurate in
the test media
laurate concentration in media: 100 to 115% of nominal concentrations.
At concentrations of 2, 3.6, and 6.4 mg/L, there was little difference
between total and soluble laurate, but approximate 8.6 mg/L and 8.0 mg/L
of soluble laurate were measured in the 11.2 and 20 mg/L test media,
corresponding to 80 and 40% of the total laurate, respectively.
Therefore, an approximate solubility limit for laurate in the test
medium was 8 to 9 mg/L.
test, precipitates were visible, particularly at the higher
concentrations (11.2 and 20.0 mg/L).
shorter-chain carboxylic acids (<12 carbons) were observed by GC–FID,
indicating that the test substance in aqueous media was present as
intact sodium laurate throughout the exposure period.
2) Effects on survival and growth
sodium laurate caused mortalities at total concentrations of 3.6 (6%),
6.4 (14%), 11 (75%), and 20 mg/L
estimated 4-, 8-, 15-, and 28-d median lethal concentrations (LC50s)
were 20, 12, 9.9, and 9.8 mg/L, respectively. Based on soluble
concentrations of laurate, LC50 values for the above time intervals were
10, 7.6, 7.6, and 7.6 mg/L. The 28-d NOEC for mortality was 2 mg/L.
fish increased in weight by 18 and 47% after 14 and 28 d, respectively.
Fish exposed to the lower concentrations (2–6.4 mg/L) all increased in
weight, and this increase was greater than that seen in control animals.
It is known that fattyacids
formed de novo and those originating from dietary lipids are easily
esterified into neutral lipids and phospholipids.Once
absorbed, laurate could perhaps be used as an additional food source by
these fish, resulting in slightly enhanced growth compared to that of
the control fish. The 28-d NOEC for growth was 6.4 mg/L.
Pseudospecific growth rates for zebrafish exposed to increasing
concentrations of sodium laurate
Time period of exposure
Pseudospecific growth rate ± SD
0 - 14
1.14 ± 1.10
1.75 ± 1.31
2.04 ± 0.89
1.50 ± 1.26
0 - 28
1.36 ± 0.54
1.72 ± 0.79
1.99 ± 0.46
1.70 ± 0.50
14 - 28
1.57 ± 1.08
1.69 ± 1.58
1.94 ± 0.92
1.90 ± 0.99
NOEC (28 d) = 6.4 mg/L (nominal), based on growth rate of Danio
rerio (OECD 305 E); RA CAS 629-25-4
NOEC (28 d) = 2 mg/L (nominal), based on mortality of Danio rerio
(OECD 305 E); RA CAS 629-25-4
No studies are available reviewing the toxicity of octanoic acid
to fish. Therefore, a read across was conducted to the analogue
substance sodium laurate. The study by Egmond et al. (1999) performed
with the read across substance was conducted according to OECD 305 E
(bioaccumulation: flow-through fish test). Danio rerio was exposed to
nominal 0, 2.0, 3.6, 6.4, 11.2 and 20.0 mg/L test item concentrations
for 28 d. The test item concentrations were monitored by GC-FID. NOEC
values were determined based on growth rate and mortality and were 6.4
mg/L and 2 mg/L, respectively. In addition an LC50 (28 d) of 9.8 mg/L
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