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EC number: 204-677-5
CAS number: 124-07-2
Table 1: Immobilisation of daphnids [%] after 48 h
Nominal test concentration
Table 1: Measured concentration of Decanoic
acid during 48 hour exposure
Measured Concentrations (mg/L)
Percent of nominal
0 Hours (new)
48 Hours (old)
Table 2: Immobility of Daphnia magna
Nominal Concentration (mg/L)
Cumulative Number of Immobilised Daphnia (Percent Immobility)
EC50 (48 h) > 21 mg/L (meas. geom. mean) based on mobility of Daphnia magna (OECD 202); RA CAS 334-48-5
Good quality read across data from decanoic acid are used as key
information to assess the short-term toxicity of octanoic acid to
aquatic invertebrates due to deficiencies of the available data on
octanoic acid. Decanoic and octanoic acids are structurally very
similar. Due to an increasing toxicity with increasing chain length from
octanoic acid (C8) to lauric acid (C12) for aquatic invertebrates, the
study using decanoic acid (C10) represents a worst case biological
profile towards aquatic invertebrates for octanoic acid (C8).
The read-across study (Ministry of the Environment of Japan,
1999), with Daphnia magna, was conducted according to OECD 202. The test
organism was exposed in a static system to a single test item
concentration of 20 mg/L (nominal). The test substance was dissolved in
0.1 mL/L dimethylformamide. An analytical monitoring was performed via
GC-MS. The study did not show any toxicity effects on the test organism
and resulted in an EC50 (48 h) of > 21 mg/L (meas. geom. mean). Based on
these data no toxicological effects on aquatic invertebrates are
expected for octanoic acid up to 21 mg/L test concentration.
Supporting studies are available for freshwater and marine
organisms conducted with octanoic acid. Two saltwater studies (1989 and
1970) are available with the test organisms Hyale plumulosa (Gammarid)
and Artemia salina resulting in LC50 (48 h) of 128 mg/L and 240 mg/L,
respectively. However, both studies were rated as insufficient for
further assessment due to limited documentation. The last available
supporting study (2001) was conducted with the freshwater organism
Daphnia magna and nominal test item concentrations of up to 10000 mg/L
were tested. The EC50 was found to be 550 mg/L.
In conclusion, octanoic acid shows no toxic effects up to a
concentration of 21 mg/L as worst case, based on read-across data.
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